Cisplatin Ingredients and Usage

The active ingredient is Cisplatin, a platinum coordination compound. The 50mg solution requires dilution and slow intravenous infusion with vigorous hydration.

Cisplatin is clinically indicated for:

• Testicular, ovarian and bladder cancers
• Head and neck squamous cell carcinoma
• Small cell and non-small cell lung cancer
• Cervical cancer and germ cell tumors

How Does Cisplatin Work?

Cisplatin exerts cytotoxic effects through DNA damage mechanisms:

1. DNA Cross-Linking: Forms intra-strand and inter-strand DNA cross-links
2. Cell Cycle Arrest: Primarily affects G2 phase of cell division
3. Apoptosis Induction: Triggers programmed cell death in cancer cells
4. Cellular Damage: Causes DNA adduct formation and replication inhibition

Cisplatin Side Effects and Warnings

Common side effects include severe nausea, vomiting, nephrotoxicity, and bone marrow suppression. Most effects require aggressive supportive care.

Serious Considerations

1. Nephrotoxicity: Requires vigorous hydration and mannitol diuresis
2. Ototoxicity: Cumulative hearing loss and tinnitus with repeated doses
3. Neurotoxicity: Peripheral sensory neuropathy may be irreversible
4. Myelosuppression: Severe leukopenia and thrombocytopenia risk
5. Electrolyte Imbalance: Magnesium wasting requires frequent monitoring

Cisplatin Storage Conditions

Cisplatin Injection requires careful storage handling:

• Store at room temperature below 25°C
• Protect from light and freezing
• Use diluted solution within 24 hours
• Discard if solution appears discolored or contains crystals
• Follow cytotoxic drug handling precautions