Cefotax Ingredients and Usage

The active ingredient is Cefotaxime Sodium, a third-generation cephalosporin antibiotic. The 1g formulation requires reconstitution before intravenous or intramuscular administration.

Cefotax is clinically indicated for:

• Bacterial meningitis and CNS infections
• Severe respiratory tract infections
• Complicated urinary tract infections
• Septicemia and gonococcal infections

How Does Cefotax Work?

Cefotax exerts bactericidal activity through specific mechanisms:

1. Cell Wall Synthesis Inhibition: Binds to essential penicillin-binding proteins
2. Broad Spectrum Coverage: Effective against Gram-positive and Gram-negative bacteria
3. Excellent CNS Penetration: Achieves therapeutic levels in cerebrospinal fluid
4. Metabolic Conversion: Partially metabolized to active desacetylcefotaxime

Cefotax Side Effects and Warnings

Common side effects include diarrhea, rash, injection site pain, and transient eosinophilia. Most reactions are mild and self-limiting.

Serious Considerations

1. CNS Toxicity: May cause seizures in patients with renal impairment
2. Hypersensitivity Reactions: Cross-reactivity possible in penicillin-allergic patients
3. Clostridium difficile Diarrhea: Risk of antibiotic-associated colitis
4. Renal Impairment: Dose adjustment required in severe kidney dysfunction
5. Hemolytic Anemia: Rare reports of immune-mediated hemolysis

Cefotax Storage Conditions

Cefotax 1g requires proper storage handling:

• Store below 25°C protected from light
• Use reconstituted solution within 24 hours if refrigerated
• Protect from moisture and freezing
• Discard if solution appears discolored or turbid
• Follow strict aseptic preparation techniques