Ceflactam Ingredients and Usage

The active ingredient is Ceftriaxone Sodium, a third-generation cephalosporin. The 1g powder requires reconstitution before intravenous or deep intramuscular administration.

Ceflactam is clinically indicated for:

• Severe respiratory tract infections
• Meningitis and CNS infections
• Complicated urinary tract infections
• Bone and joint infections

How Does Ceflactam Work?

Ceflactam exerts bactericidal activity through specific mechanisms:

1. Cell Wall Synthesis Inhibition: Binds to penicillin-binding proteins
2. Bacterial Lysis: Disrupts bacterial cell wall integrity
3. Broad Spectrum: Covers wide range of pathogens
4. Long Half-life: Allows once or twice daily dosing

Ceflactam Side Effects and Warnings

Common side effects include diarrhea, rash, injection site reactions, and elevated liver enzymes. Most reactions are mild and temporary.

Serious Considerations

1. Biliary Sludge: May cause pseudocholelithiasis with prolonged use
2. Hemolytic Anemia: Risk of immune-mediated hemolytic reactions
3. Calcium Precipitation: Do not mix with calcium-containing solutions in neonates
4. Cross-reactivity: Contraindicated in patients with cephalosporin allergy
5. Renal/Hepatic Impairment: Monitor in patients with organ dysfunction

Ceflactam Storage Conditions

Ceflactam 1g requires proper storage conditions:

• Store below 25°C protected from light
• Use reconstituted solution within 24 hours if refrigerated
• Protect from moisture and freezing
• Discard if solution appears discolored
• Follow aseptic preparation guidelines