Carplatu Ingredients and Usage

The active ingredient is Carboplatin, a second-generation platinum compound. The 150mg/15ml formulation is administered as intravenous infusion over 15-60 minutes following dilution.

Carplatu is clinically indicated for:

• Advanced ovarian cancer treatment
• Small cell and non-small cell lung cancer
• Head and neck squamous cell carcinoma
• Germ cell tumors and bladder cancer

How Does Carplatu Work?

Carboplatin exerts its anticancer effects through DNA damage mechanisms:

1. DNA Cross-Linking: Forms covalent bonds with DNA purine bases
2. Cell Cycle Arrest: Primarily affects G2 phase of cell division
3. Apoptosis Induction: Triggers programmed cell death in cancer cells
4. Reduced Nephrotoxicity: Lower kidney toxicity compared to cisplatin

Carplatu Side Effects and Warnings

Common side effects include bone marrow suppression, nausea, vomiting, and hair loss. Most effects are manageable with supportive care.

Serious Considerations

1. Myelosuppression: Severe thrombocytopenia and neutropenia require regular blood count monitoring
2. Dosing Calculation: Dose based on Calvert formula using glomerular filtration rate
3. Hypersensitivity Reactions: Anaphylaxis risk requires premedication and monitoring
4. Ototoxicity and Neurotoxicity: Cumulative peripheral neuropathy with repeated cycles
5. Renal Impairment: Dose adjustment necessary for patients with kidney dysfunction

Carplatu Storage Conditions

Carplatu Injection requires careful storage handling:

• Store at room temperature below 30°C
• Protect from light and freezing
• Use diluted solution within 8 hours
• Discard if solution appears discolored or contains particles
• Follow cytotoxic drug handling precautions