Caden 6mg Ingredients and Usage

The active ingredient is Adenosine, an endogenous purine nucleoside. The 6mg strength is supplied as a sterile solution for rapid intravenous bolus administration.

Caden is clinically indicated for:

• Conversion of PSVT: First-line treatment for terminating paroxysmal supraventricular tachycardia, including AV nodal reentrant tachycardia and AV reentrant tachycardia.
• Pharmacological Stress Testing: Used as a coronary vasodilator in myocardial perfusion imaging studies for patients unable to exercise.
• Diagnostic Tool: Helps in the differential diagnosis of broad and narrow complex tachycardias.

How Does Caden Work?

Adenosine exerts its antiarrhythmic effects through multiple mechanisms with an extremely rapid onset and short duration of action:

1. AV Node Depression: Adenosine activates A1 adenosine receptors, leading to hyperpolarization of atrial myocytes and slowing of conduction through the AV node.
2. Reentry Circuit Interruption: By prolonging the AV nodal refractory period, it interrupts the reentrant pathways responsible for PSVT.
3. Coronary Vasodilation: Activates A2A receptors, causing coronary artery vasodilation, which is utilized in stress testing.
4. Rapid Metabolism: Has an extremely short half-life (less than 10 seconds) due to rapid uptake by erythrocytes and endothelial cells.

Caden 6mg Side Effects and Warnings

Due to its potent physiological effects, Adenosine commonly causes transient side effects that typically resolve quickly. Common effects include facial flushing, dyspnea, chest pressure, and dizziness.

Serious Warnings and Precautions:

1. Transient Arrhythmias: May cause transient atrial fibrillation, bradycardia, or ventricular arrhythmias. Continuous ECG monitoring is essential during administration.
2. Bronchoconstriction: Contraindicated in patients with asthma or severe COPD due to risk of bronchospasm.
3. Heart Block: May cause advanced heart block in patients with pre-existing conduction abnormalities. Use with caution in patients with first-degree AV block or bundle branch block.
4. Drug Interactions: Methylxanthines (theophylline, caffeine) antagonize adenosine effects. Dipyridamole potentiates adenosine effects.
5. Administration: Must be given as rapid IV push followed by saline flush to ensure proper delivery to central circulation.

Caden 6mg Storage Conditions

Caden Injection requires specific storage conditions to maintain stability:

• Store at controlled room temperature between 15°C and 30°C (59°F and 86°F).
• Protect from freezing and excessive heat.
• Inspect solution before use – should be clear and colorless.
• Discard any unused portion as the vial is for single use only.
• Do not refrigerate as crystallization may occur.