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Brexin Tablets 20 mg (1 Box = 20 Tablets)
Brexin Tablet contains Piroxicam-beta-cyclodextrin, a nonsteroidal anti-inflammatory drug (NSAID) with improved solubility and faster absorption compared to conventional piroxicam. Buy Brexin online at PakMeds.
Original price was: ₨ 792.₨ 710Current price is: ₨ 710.
| Manufacturer | Chiesi Farmaceutici S.p.A. (or local authorized distributor) |
| Active Ingredients | Piroxicam-beta-cyclodextrin |
| Medicine Strength | 20 mg per Tablet |
| Number Per Pack | Typically 10 Tablets |
| Requires Prescription? | Yes |
| Generics | Piroxicam-beta-cyclodextrin |
Brexin Ingredients and Usage
The active ingredient is Piroxicam-beta-cyclodextrin, a complex formed between piroxicam and beta-cyclodextrin that enhances the drug’s solubility and absorption. The 20 mg tablet is designed for oral administration, typically taken once daily.
Brexin is clinically indicated for the short-term treatment of:
- Acute Musculoskeletal Disorders: Including sprains, strains, and other traumatic injuries.
- Postoperative Pain: Management of pain following surgical procedures.
- Primary Dysmenorrhea: Treatment of painful menstrual cramps.
- Acute Gout: Management of acute gout attacks.
How Does Brexin Work?
Brexin belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) and works through multiple mechanisms to provide pain relief and reduce inflammation:
- Cyclooxygenase Inhibition: Piroxicam inhibits both COX-1 and COX-2 enzymes, which are responsible for the production of prostaglandins – chemical mediators that promote pain, inflammation, and fever.
- Enhanced Absorption: The beta-cyclodextrin complex increases the solubility of piroxicam, leading to faster absorption and a more rapid onset of action compared to conventional piroxicam formulations.
- Anti-inflammatory Action: By reducing prostaglandin synthesis, Brexin decreases inflammation, swelling, and associated pain.
- Analgesic Effect: The drug provides effective pain relief by interfering with pain signal transmission in the peripheral nervous system.
Brexin Side Effects and Warnings
As with all NSAIDs, Brexin may cause side effects, particularly with long-term use or higher doses. Common side effects may include gastrointestinal discomfort, nausea, dyspepsia, and dizziness.
Serious Warnings and Precautions:
- Gastrointestinal Risks: NSAIDs, including Brexin, increase the risk of serious gastrointestinal adverse events such as bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk.
- Cardiovascular Thrombotic Events: NSAIDs may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with the duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk.
- Renal Toxicity: Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Use with caution in patients with renal impairment, heart failure, or liver dysfunction.
- Contraindications: Brexin is contraindicated in patients with known hypersensitivity to piroxicam, other NSAIDs, or any component of the formulation. It should not be used in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Brexin Storage Conditions
Brexin Tablets should be stored properly to maintain their efficacy and stability:
- Store at controlled room temperature, between 15°C and 30°C (59°F and 86°F).
- Keep the tablets in their original blister packaging to protect from moisture and light.
- Keep out of reach and sight of children.
- Do not use after the expiration date printed on the packaging.
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