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Benzibiotic 1.2 Million Unit (1 Injection)
Benzibiotic 1.2 Million IU Injection contains Benzathine Benzylpenicillin, a long-acting form of penicillin. Benzibiotic is a prescription-only injectable medicine administered in a clinical setting. Buy Benzibiotic antibiotic online at PakMeds with a valid prescription.
Original price was: ₨ 119.₨ 110Current price is: ₨ 110.
| Manufacturer | Typically a local or regional pharmaceutical company |
| Active Ingredients | Benzathine Benzylpenicillin (or Benzathine Penicillin G) |
| Medicine Strength | 1.2 Million IU (1,200,000 IU) per vial |
| Formulation | Lyophilized Powder for Deep Intramuscular (IM) Injection |
| Requires Prescription? | Yes (Specialist/Clinic use only) |
| Generics | Benzathine Penicillin G, Benzathine Benzylpenicillin |
Benzibiotic 1.2 Million IU Ingredients and Usage
The active ingredient is Benzathine Benzylpenicillin, a highly insoluble salt of penicillin. It is supplied as a powder for suspension that must be reconstituted with Sterile Water for Injection or saline.
The 1.2 Million IU strength is clinically indicated for:
- Primary, Secondary, and Early Latent Syphilis: A single dose is often curative for early stages of the disease.
- Prevention of Rheumatic Fever: Administered monthly to prevent Group A Streptococcal infections, which can trigger recurrent rheumatic fever and subsequent rheumatic heart disease.
- Treatment of Mild to Moderate Upper Respiratory Infections: Caused by susceptible streptococci.
How Does Benzibiotic Work?
Benzathine Benzylpenicillin is a beta-lactam antibiotic with a unique depot effect, allowing for prolonged action:
- Long-Acting Depot: After deep intramuscular injection, the drug forms a poorly soluble crystal depot at the injection site.
- Slow Release: The antibiotic is then slowly released from this depot into the circulation over a period of 2 to 4 weeks.
- Cell Wall Inhibition: The released Benzylpenicillin acts by inhibiting the final transpeptidase step in the synthesis of the bacterial cell wall (specifically, peptidoglycan), leading to osmotic instability, cell lysis, and death of susceptible bacteria (bactericidal action).
Benzibiotic 1.2 Million IU Side Effects and Warnings
As a penicillin product, the primary concern is the risk of allergic reactions. The injection itself can also be painful.
Black Box Warnings and Critical Precautions:
- Hypersensitivity (Allergy): Penicillin is a common allergen. Severe, life-threatening anaphylaxis (allergic shock) can occur. Patients must be carefully screened for any previous penicillin or cephalosporin allergy. Emergency facilities must be immediately available during and after injection.
- Injection Technique: The drug must be given via deep intramuscular injection only (e.g., in the upper outer quadrant of the buttock). NEVER inject intravenously (IV), as accidental IV administration can cause severe cardiorespiratory arrest and death (Hoigné syndrome) due to the large particle size of the suspension.
- Injection Pain: The thick suspension can cause significant pain and irritation at the injection site. Rotation of injection sites is recommended for long-term therapy.
- Jarisch-Herxheimer Reaction: Used in the treatment of syphilis, the rapid killing of Treponema pallidum can cause a temporary reaction characterized by fever, headache, and myalgia. This is a common and usually self-limiting immune reaction.
Benzibiotic 1.2 Million IU Storage Conditions
Benzibiotic is supplied as a powder requiring specific storage and handling:
- Store the unopened vials at controlled room temperature, typically between 20°C and 25°C (68°F and 77°F).
- Reconstitution: The powder must be reconstituted with the appropriate diluent (e.g., Sterile Water for Injection) immediately before use.
- Suspension: The resulting suspension must be visibly uniform and administered immediately after preparation.
- Needle Size: A longer needle (e.g., 1.5 to 2 inch) is required for deep IM injection to ensure proper placement.
