Baj-prolol 5 mg/5 mL Ingredients and Usage

The active ingredient is Esmolol Hydrochloride. The typical concentration for a 5 mL vial is 10 mg/mL (total 50 mg). Since the user specified 5 mg/5 mL, this suggests a very dilute concentration of 1 mg/mL, which is often a pre-mixed, ready-to-use solution for infusion.

Esmolol is clinically indicated for the rapid, temporary treatment of:

• Supraventricular Tachyarrhythmias: Rapid ventricular rate control in Atrial Fibrillation (AF) or Atrial Flutter.
• Perioperative Tachycardia and/or Hypertension: Managing rapid heart rate and high blood pressure during surgery or in the immediate post-operative period.
• Acute Myocardial Ischemia: Used in some settings to reduce oxygen demand in acute coronary syndrome.

How Does Baj-prolol Work?

Esmolol is an ultra-short-acting Class II antiarrhythmic drug. Its mechanism is highly beneficial in emergency settings:

1. Selective Beta-1 Blockade: Esmolol is a highly selective antagonist of the beta-1 adrenergic receptors in the heart. Blocking these receptors prevents adrenaline and noradrenaline from increasing heart rate and contractility.
2. Reduced Cardiac Workload: This action reduces chronotropy (heart rate), dromotropy (conduction velocity), and inotropy (contractility). This rapidly lowers the heart rate and blood pressure, reducing myocardial oxygen demand.
3. Rapid Onset/Offset: Esmolol is metabolized rapidly by esterases in the red blood cells, not the liver or kidneys. It has an elimination half-life of only 9 minutes. This ultra-short duration allows the medical team to quickly adjust the infusion rate or stop the drug, with effects dissipating almost immediately.

Baj-prolol 5 mg/5 mL Side Effects and Warnings

Due to its potent effects, careful titration is required. The most common side effect is often dose-related.

Serious Warnings and Critical Precautions:

1. Hypotension and Bradycardia: Excessive or rapid administration can cause severe and symptomatic hypotension (low blood pressure) and bradycardia (slow heart rate). Continuous ECG and BP monitoring is mandatory.
2. Cardiac Failure: Beta-blockers can depress myocardial contractility and precipitate or worsen congestive heart failure. It is contraindicated in patients with uncompensated heart failure, cardiogenic shock, or severe sinus bradycardia.
3. Bronchospasm: Although highly selective, Esmolol should be used with extreme caution in patients with bronchospastic diseases (e.g., severe asthma or COPD) as it may cause bronchospasm.
4. Extravasation Risk: The standard 10 mg/mL concentration is highly irritating. Accidental extravasation (leakage out of the vein) can cause severe tissue necrosis. The dilute 1 mg/mL solution is generally less irritating.

Baj-prolol 5 mg/5 mL Storage Conditions

Esmolol injection requires controlled storage:

• Store the unopened vials at controlled room temperature, typically between 20°C and 25°C (68°F and 77°F). Do not freeze.
• Protect from Light: Keep the product in the original carton until use.
• Inspection: The solution should be clear and colorless. Do not use if the solution is discolored or contains particulate matter.
• Administration: The drug is typically administered via a loading dose followed by a continuous, highly monitored IV infusion, with the rate adjusted according to the patient’s heart rate and blood pressure response.