Aclovir 250 mg Ingredients and Usage

Acyclovir is a synthetic nucleoside analogue. The 250 mg strength is supplied as a sterile
powder that must be reconstituted and given slowly via IV infusion.

It is clinically used for the treatment of:

• Herpes Simplex Encephalitis (life-threatening brain infection)
• Severe initial genital herpes
• HSV infections in immunocompromised patients (HIV/AIDS, post-transplant, cancer therapy)
• Varicella-Zoster Virus infections (including Shingles) in immunocompromised patients
• Neonatal Herpes Simplex infections

How Does Aclovir 250 mg Work?

Acyclovir targets viral DNA replication. It is selectively activated inside virus-infected
cells through a three-step process:

1. Selective Activation: Viral thymidine kinase (TK) activates Acyclovir inside infected cells.
2. Conversion: Acyclovir is converted to its active form, Acyclovir triphosphate.
3. Inhibition: Acyclovir triphosphate blocks viral DNA synthesis by terminating the growing DNA chain.

This prevents HSV and VZV from multiplying and spreading in the body.

Aclovir 250 mg Side Effects and Warnings

Aclovir Injection is administered only by trained healthcare professionals. Common side
effects may include:

• Nausea or vomiting
• Headache
• Diarrhea
• Pain, redness, or inflammation at the injection site

Serious Side Effects and Warnings:

• Kidney Toxicity: Rapid infusion or inadequate hydration can cause Acyclovir to crystallize in the kidneys, leading to kidney damage or acute renal failure. It must be infused slowly over at least one hour with adequate hydration.
• Neurotoxicity: High doses or use in patients with kidney impairment may cause confusion, agitation, hallucinations, tremors, or seizures. Monitoring is required.
• Contraindication: Do not use in patients allergic to Acyclovir or Valacyclovir.
  Seek immediate medical attention for allergic reactions (hives, difficulty breathing,
  swelling of the face/lips) or signs of kidney problems (reduced urination, leg/ankle
  swelling).

Aclovir 250 mg Storage Conditions

• Store unopened vials below 25°C (77°F) and protect from light.
• Use reconstituted solution immediately; stability may vary by manufacturer.
• Must be diluted further before slow IV infusion.
• Not for rapid injection, intramuscular, or subcutaneous use.
• Keep out of reach of children.