Abriva Plus Ingredients and Usage

Abriva Plus contains two Direct-Acting Antiviral (DAA) agents:

• Sofosbuvir (400mg) – an inhibitor of the HCV NS5B RNA polymerase.
• Velpatasvir (100mg) – an inhibitor of the HCV NS5A protein.

This medicine is used to treat all major HCV genotypes (pan-genotypic) in adults with or without compensated cirrhosis.

For patients with decompensated cirrhosis (Child-Pugh B or C), Abriva Plus is typically given together with Ribavirin.

How Does Abriva Plus Work?

Abriva Plus targets two essential proteins used by the Hepatitis C virus to multiply:

1. Sofosbuvir is converted in the body to its active form, which blocks
   the NS5B RNA-dependent RNA polymerase. This stops the virus from producing new RNA,
   halting replication.
2. Velpatasvir inhibits the NS5A protein, which is critical for viral
   replication and virion assembly.

By blocking the virus at two different stages, Abriva Plus dramatically reduces viral load and significantly increases the likelihood of clearing the infection completely.

Abriva Plus Side Effects and Warnings

Common side effects include:

• Headache
• Fatigue or tiredness
• Nausea
• Insomnia
• Diarrhea

Serious Warnings and Precautions:

Hepatitis B Reactivation: Patients with current or previous HBV Infection must be screened before starting therapy. HBV reactivation can occur and requires monitoring during and after treatment.

Serious Bradycardia: Co-administration with the heart medicine Amiodarone can cause life-threatening slowing of the heart rate. This combination should be avoided unless no alternatives exist.

Drug Interactions: Abriva Plus should not be taken with medications such as Rifampin, Carbamazepine, Phenytoin, or herbal supplements like St. John’s Wort, as these can reduce antiviral effectiveness.

Abriva Plus Storage Conditions

• Store at room temperature between 20°C and 25°C (68°F–77°F).
• Keep tablets in the original container, tightly closed.
• Protect from moisture, heat, and direct sunlight.
• Keep out of the reach of children and pets.

Always follow your doctor’s complete treatment plan to ensure the highest chance of cure.